Metabolism of a lipid nanoemulsion resembling low-density lipoprotein in patients with grade III obesity

Introduction: Obesity increases triglyceride levels and decreases high-density lipoprotein concentrations in plasma. Artificial emulsions resembling lipidic plasma lipoprotein structures have been used to evaluate low-density lipoprotein metabolism. In grade III obesity, low density lipoprotein metabolism is poorly understood. Objective: To evaluate the kinetics with which a cholesterol-rich emulsion (called a low-density emulsion) binds to low-density lipoprotein receptors in a group of patients with grade III obesity by the fractional clearance rate. Methods: A low-density emulsion was labeled with [14C]-cholesterol ester and [³H]-triglycerides and injected intravenously into ten normolipidemic non-diabetic patients with grade III obesity [body mass index higher than 40 kg/m²] and into ten non-obese healthy controls. Blood samples were collected over 24 hours to determine the plasma decay curve and to calculate the fractional clearance rate. Results: There was no difference regarding plasma levels of total cholesterol or low-density lipoprotein cholesterol between the two groups. The fractional clearance rate of triglycerides was 0.086 ± 0.044 in the obese group and 0.122 ± 0.026 in the controls (p = 0.040), and the fractional clearance rate of cholesterol ester (h-1) was 0.052 ± 0.021 in the obese subjects and 0.058 ± 0.015 (p = 0.971) in the controls. Conclusion: Grade III obese subjects exhibited normal low-density lipoprotein removal from plasma as tested by the nanoemulsion method, but triglyceride removal was slower.

Tratamento do aneurisma de arco e aorta descendente: abordagem cirúrgica em uma etapa / Single stage surgical approach for arch and descending thoracic aorta aneurysm

Paciente de 61 anos procurou atendimento médico com quadro clínico de infecção pulmonar. O estudo radiológico de tóraz revelou aneurisma de aorta descendente com comprometimento do arco aórtico. Ressalta-se a correção cirúrgica em uma única etapa, por meio de abordagem operatória não convencional, que possibilitou a correção total do aneurisma

Avaliação do metabolismo de uma emulsão lipídica rica em colesterol em pacientes com obesidade grau III / Metabolism of a lipid emulsion resembling low-density lipoprotein in patients with obesity grade III

Emulsões artificiais semelhante as lipoproteínas plasmáticas são usadas na avaliação do metabolismo da lipoproteína de baixa densidade(LDL) porém em obesos grau III esse metabolismo lipídico ainda não é bem conhecido.O objetivo do estudo foi avaliar a cinética de uma emulsão rica em colesterol que se liga a receptores de LDL e mimetiza o comportamento do colesterol endógeno,em obesos grau III.A emulsão artificial de LDL foi marcada com colesterol éster-[14C] e triglicérides-[3H], injetada em 10 obesos grau III e 10 controles / Artificial emulsions of defined composition resembling the lipidic structure of the plasma lipoproteins have been used to evaluate low- density lipoprotein (LDL) metabolism.In morbid obesity,the LDL metabolism is poorly understood.The purpose of this study was to evaluate the kinetic of a cholesterol-rich emulsion that binds to the LDL receptors,called LDE, in a group of morbid obesity.LDE was labeled with [14C]-cholesteryl ester and [3H]-triglycerides and injected intravenously into 10 patients with morbid obesity and 10 controls...